Publications – Jim Wikel
Lobb, Karen L.; Hipskind, Philip A.; Aikins, James A.; Alvarez, Enrique; Cheung, Yiu-Yin; Considine, Eileen L.; De Dios, Alfonso; Durst, Gregory L.; Ferritto, Rafael; Grossman, Cora Sue; Giera, Deborah D.; Hollister, Beth A.; Huang, Zhongping; Iversen, Philip W.; Law, Kevin L.; Li, Tiechao; Lin, Ho-Shen; Lopez, Beatriz; Lopez, Jose E.; Cabrejas, Luisa M. Martin; McCann, Denis J.; Molero, Victoriano; Reilly, John E.; Richett, Michael E.; Shih, Chuan; Teicher, Beverly; Wikel, James H.; White, Wesley T.; Mader, Mary M. Acyl Sulfonamide Anti-Proliferatives: Benzene Substituent Structure-Activity Relationships for a Novel Class of Antitumor Agents. Journal of Medicinal Chemistry (2004), 47(22), 5367-5380. CODEN: JMCMAR ISSN:0022-2623. AN 2004:773118 CAPLUS
Bednarczyk, Dallas; Ekins, Sean; Wikel, James H.; Wright, Stephen H. Influence of
molecular structure on substrate binding to the human organic cation transporter,
hOCT1. Molecular Pharmacology (2003), 63(3), 489-498. CODEN: MOPMA3
ISSN:0026-895X. CAN 139:254713 AN 2003:218815 CAPLUS
Mader, Mary M.; Considine, Eileen L.; de Dios, Alfonso; Durst, Gregory; Ferrito, Rafael;
Grossman, Cora Sue; Hipskind, Philip A.; Li, Tiechao; Lin, Ho-shen; Lobb, Karen; Lopez, Beatriz; Lopez, Jose E.; Martin, Luisa; Richett, Michael E.; Shih, Chuan; White, Wesley T.; Wikel, James H.; Teicher, Beverly; Alvarez, Enrique; Corbett, Thomas H.; Cheung, Yiu-Yen; Dinn, Sean R.; Huang, Zhongping; Reilly, John E. Acyl sulfonamide antiproliferatives: Structure-activity relationships for novel antitumor agents. Abstracts of Papers, 225th ACS National Meeting, New Orleans, LA, United States, March 23-27, 2003 (2003), MEDI-075. CODEN: 69DSA4 AN 2003:184046 CAPLUS
Ekins, Sean; Ring, Barbara J.; Bravi, Gianpaolo; Wikel, James H.; Wrighton, Steven A.
Predicting drug-drug interactions in silico using pharmacophores: A paradigm for the
next millennium. IUL Biotechnology Series (2000), 2(Pharmacophore), 269-299.
CODEN: IBSUA9 CAN 137:362253 AN 2002:369053 CAPLUS
Ekins, Sean; Crumb, William J.; Sarazan, R. Dustan; Wikel, James H.; Wrighton,
Steven A. Three-dimensional quantitative structure-activity relationship for
inhibition of human ether-a-go-go-related gene potassium channel. Journal of
Pharmacology and Experimental Therapeutics (2002), 301(2), 427-434. CODEN:
JPETAB ISSN:0022-3565. CAN 137:304266 AN 2002:336083 CAPLUS
Ekins, Sean; Kim, Richard B.; Leake, Brenda F.; Dantzig, Anne H.; Schuetz, Erin G.;
Lan, Lu-Bin; Yasuda, Kazuto; Shepard, Robert L.; Winter, Mark A.; Schuetz, John D.;
Wikel, James H.; Wrighton, Steven A. Application of three-dimensional quantitative
structure-activity relationships of P-glycoprotein inhibitors and substrates.
Molecular Pharmacology (2002), 61(5), 974-981. CODEN: MOPMA3 ISSN:0026-895X. CAN 137:103398 AN 2002:335671 CAPLUS
Ekins, Sean; Kim, Richard B.; Leake, Brenda F.; Dantzig, Anne H.; Schuetz, Erin G.;
Lan, Lu-Bin; Yasuda, Kazuto; Shepard, Robert L.; Winter, Mark A.; Schuetz, John D.;
Wikel, James H.; Wrighton, Steven A. Three-dimensional quantitative structure-activity
relationships of inhibitors of P-glycoprotein. Molecular Pharmacology (2002),
61(5), 964-973. CODEN: MOPMA3 ISSN:0026-895X. CAN 137:87811 AN 2002:335670
CAPLUS
Ekins, Sean; Durst, Gregory L.; Stratford, Robert E.; Thorner, David A.; Lewis, Richard;
Loncharich, Richard J.; Wikel, James H.. Three-Dimensional Quantitative
Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus
Replication. Journal of Chemical Information and Computer Sciences (2001), 41(6),
1578-1586. CODEN: JCISD8 ISSN:0095-2338. CAN 136:189 AN 2001:682670 CAPLUS
Ekins, S.; Waller, C. L.; Swaan, P. W.; Cruciani, G.; Wrighton, S. A.; Wikel, J. H..
Progress in predicting human ADME parameters in silico. Journal of Pharmacological
and Toxicological Methods (2001), Volume Date 2000, 44(1), 251-272.
CODEN: JPTMEZ ISSN:1056-8719. CAN 135:70448 AN 2001:219710 CAPLUS
Ekins, Sean; Bravi, Gianpaolo; Binkley, Shelly; Gillespie, Jennifer S.; Ring,
Barbara J.; Wikel, James H.; Wrighton, Steven A. Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors. Drug Metabolism and Disposition (2000), 28(8), 994-1002. CODEN: DMDSAI ISSN:0090-9556. CAN 133:246805 AN 2000:522258 CAPLUS
Bravi, Gianpaolo; Wikel, James H.. Application of MS-WHIM descriptors: 3.
Prediction of molecular properties. Quantitative Structure-Activity Relationships
(2000), 19(1), 39-49. CODEN: QSARDI ISSN:0931-8771. CAN 133:263 AN 2000:241148
CAPLUS
Bravi, Gianpaolo; Wikel, James H.. Application of MS-WHIM descriptors: 1.
Introduction of new molecular surface properties and 2. Prediction of binding affinity
data. Quantitative Structure-Activity Relationships (2000), 19(1), 29-38.
CODEN: QSARDI ISSN:0931-8771. CAN 133:99057 AN 2000:241146 CAPLUS
Herron, David K.; Goodson, Theodore, Jr.; Wiley, Michael R.; Weir, Leonard C.;
Kyle, Jeffrey A.; Yee, Ying K.; Tebbe, Ann Louise; Tinsley, Jennifer M.; Mendel, David;
Masters, John J.; Franciskovich, Jeffry B.; Sawyer, J. Scott; Beight, Douglas W.; Ratz,
Andrew M.; Milot, Guy; Hall, Steven E.; Klimkowski, Valentine J.; Wikel, James H.;
Eastwood, Brian J.; Towner, Richard D.; Gifford-Moore, Donetta S.; Craft, Trelia J.;
Smith, Gerald F. 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa.
Journal of Medicinal Chemistry (2000), 43(5), 859-872. CODEN: JMCMAR
ISSN:0022-2623. CAN 132:273840 AN 2000:122180 CAPLUS
Ekins, Sean; Bravi, Gianpaolo; Binkley, Shelly; Gillespie, Jennifer S.; Ring, Barbara J.; Wikel, James H.; Wrighton, Steven A. Three and four dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2D6 inhibitors. Pharmacogenetics (1999), 9(4), 477-489. CODEN: PHMCEE ISSN:0960-314X. CAN 132:146140 AN 1999:635012 CAPLUS
Ekins, Sean; Bravi, Gianpaolo; Wikel, James H.; Wrighton, Steven A.
Three-dimensional-quantitative structure activity relationship analysis of
cytochrome P-450 3A4 substrates. Journal of Pharmacology and Experimental
Therapeutics (1999), 291(1), 424-433. CODEN: JPETAB ISSN:0022-3565.
CAN 131:333951 AN 1999:632749 CAPLUS
Ekins, Sean; Bravi, Gianpaolo; Binkley, Shelly; Gillespie, Jennifer S.; Ring, Barbara J.;
Wikel, James H.; Wrighton, Steven A. Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors. Journal of
Pharmacology and Experimental Therapeutics (1999), 290(1), 429-438. CODEN: JPETAB ISSN:0022-3565. CAN 131:208582 AN 1999:416155 CAPLUS
Bastian, Jolie A.; Chirgadze, Nickolay; Denney, Michael L.; Gifford-Moore, Donetta S.;
Sall, Daniel J.; Smith, Gerald F.; Wikel, James H.. Diamino benzo[b]thiophene
derivatives as a novel class of active site directed thrombin inhibitors. 3.
Enhancing activity by imposing conformational restriction in the C-4'' side chain.
Bioorganic & Medicinal Chemistry Letters (1999), 9(3), 363-368. CODEN: BMCLE8
ISSN:0960-894X. CAN 130:281938 AN 1999:170580 CAPLUS
Ekins, Sean; Bravi, Gianpaolo; Ring, Barbara J.; Gillespie, Todd A.; Gillespie,
Jennifer S.; Vandenbranden, Mark; Wrighton, Steven A.; Wikel, James H..
Three-dimensional quantitative structure activity relationship analyses of
substrates for CYP2B6. Journal of Pharmacology and Experimental Therapeutics
(1999), 288(1), 21-29. CODEN: JPETAB ISSN:0022-3565. CAN 130:193515
AN 1999:24861 CAPLUS
Takeuchi, Kumiko; Kohn, Todd J.; True, Timothy A.; Mais, Dale E.; Wikel, James H.;
Utterback, Barbara G.; Wyss, Virginia L.; Jakubowski, Joseph A. Development of
Dual-Acting Agents for Thromboxane Receptor Antagonism and Thromboxane Synthase
Inhibition. 3. Synthesis and Biological Activities of Oxazolecarboxamide-Substituted
w-Phenyl-w-(3-pyridyl)alkenoic Acid Derivatives and Related Compounds.
Journal of Medicinal Chemistry (1998), 41(27), 5362-5374. CODEN: JMCMAR
ISSN:0022-2623. CAN 130:110182 AN 1998:756609 CAPLUS
Sall, Daniel J.; Briggs, Stephen L.; Chirgadze, Nickolay Y.; Clawson, David K.;
Gifford-Moore, Donetta S.; Klimkowski, Valentine J.; McCowan, Jefferson R.; Smith,
Gerald F.; Wikel, James H.. Dibasic benzo[b]thiophene derivatives as a novel class
of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal
(S2) binding site. Bioorganic & Medicinal Chemistry Letters (1998), 8(18),
2527-2532. CODEN: BMCLE8 ISSN:0960-894X. CAN 130:3734 AN 1998:660072 CAPLUS
Kohn, Todd J.; Jakubowski, Joseph A.; Mais, Dale E.; True, Timothy A.; Utterback,
Barbara G.; Wikel, James H.; Wyss, Virginia L.; Takeuchi, Kumiko. Development and
SAR of dual-acting TRA/TSI agents, oxazole amide substituted phenyl-(3-pyridyl)-alkenoic acids. Book of Abstracts, 216th ACS National Meeting, Boston, August 23-27 (1998), MEDI-082. CODEN: 66KYA2 AN 1998:529568 CAPLUS
Higgs, Richard E.; Bemis, Kerry G.; Watson, Ian A.; Wikel, James H.. Experimental
Designs for Selecting Molecules from Large Chemical Databases. Journal of Chemical
Information and Computer Sciences (1997), 37(5), 861-870. CODEN: JCISD8
ISSN:0095-2338. CAN 127:161267 AN 1997:590892 CAPLUS
Sall, Daniel J.; Arfsten, Ann E.; Bastian, Jolie A.; Denney, Michael L.; Harms, Cathy S.;
McCowan, Jefferson R.; Morin, John M., Jr.; Rose, Jack W.; Scarborough, Robert M.;
Smyth, Mark S.; Um, Suzane L.; Utterback, Barbara G.; Vasileff, Robert T.; Wikel,
James H.; Wyss, Virginia L.; Jakubowski, Joseph A. Use of Conformationally Restricted
Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor
Antagonists. Journal of Medicinal Chemistry (1997), 40(18), 2843-2857.
CODEN: JMCMAR ISSN:0022-2623. CAN 127:190611 AN 1997:526715 CAPLUS
Wikel, James H.; Dow, Ernst R.; Heathman, Michael. Interpretative neural networks for
QSAR. Network Science [Electronic Publication] (1996), 2(3, Avail.
URL: http://www.awod.com/netsci/Issues/Mar96/feature1.html), No pp. Given.
CODEN: NESCF2 CAN 124:331669 AN 1996:315161 CAPLUS
Wikel, J. H.; Bemis, K. G.; Kurz, Ken; Denney, M. L.; Main, Bradley W.; Moore, R. A.;
Smith, Tommy; Shingleton, Larry; Holland, D. R. Comparative QSAR studies of two
series of 1,4-dihydropyridines as slow calcium channel blockers. Drug Design and
Discovery (1994), 11(1), 1-14. CODEN: DDDIEV ISSN:1055-9612. CAN 121:221033
AN 1994:621033 CAPLUS
Wikel, James H.; Sofia, Michael J.; Saussy, David L., Jr.; Nemis, Kerry G.
QSAR study of ortho-phenylphenol leukotriene B4 receptor antagonists.
Bioorg. Med. Chem. Lett. (1994), 4(6), 795-800. CODEN: BMCLE8 ISSN:0960-894X. CAN 121:49605 AN 1994:449605 CAPLUS
Wikel, James H.; Denney, Michael L.; Vasileff, Robert T. Convenient synthesis of
the thieno[3,2-c]pyridine nucleus. Journal of Heterocyclic Chemistry (1993),
30(1), 289-90. CODEN: JHTCAD ISSN:0022-152X. CAN 120:134328 AN 1994:134328
CAPLUS
Wikel, James H.; Dow, Ernst R. The use of neural networks for variable selection in
QSAR. Bioorganic & Medicinal Chemistry Letters (1993), 3(4), 645-51.
CODEN: BMCLE8 ISSN:0960-894X. CAN 119:94673 AN 1993:494673 CAPLUS
McQuaid, Loretta A.; Smith, Edward C. R.; Lodge, David; Pralong, Etienne; Wikel,
James H.; Calligaro, David O.; O'Malley, Patrick J. 3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the
N-methyl-D-aspartate receptor complex. Journal of Medicinal Chemistry (1992),
35(18), 3423-5. CODEN: JMCMAR ISSN:0022-2623. CAN 117:163352 AN 1992:563352
CAPLUS
Holland, Donald R.; Wikel, James H.; Kauffman, Raymond F.; Smallwood, Jeffrey K.;
Zimmerman, Karen M.; Utterback, Barbara G.; Turk, John A.; Steinberg, Mitchell I.
LY249933: a cardioselective 1,4-dihydropyridine with positive inotropic activity.
Journal of Cardiovascular Pharmacology (1989), 14(3), 483-91. CODEN: JCPCDT
ISSN:0160-2446. CAN 111:166790 AN 1989:566790 CAPLUS
Fuller, Ray W.; Hahn, Richard A.; Snoddy, Harold D.; Wikel, James H..
Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-
tetrahydropyridine (MPTP). Biochemical Pharmacology (1984), 33(19), 2957-60.
CODEN: BCPCA6 ISSN:0006-2952. CAN 102:1476 AN 1985:1476 CAPLUS
Wikel, J. H.; Paget, C. J.; DeLong, D. C.; Nelson, J. D.; Wu, C. Y. E.;
Paschal, J. W.; Dinner, A.; Templeton, R. J.; Chaney, M. O.; et al.
Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-
[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus
multiplication. Journal of Medicinal Chemistry (1980), 23(4), 368-72.
CODEN: JMCMAR ISSN:0022-2623. CAN 92:163907 AN 1980:163907 CAPLUS
Wikel, James H.; Paget, Charles J. Synthesis of s-triazole[3,4-b]benzothiazoles.
Journal of Organic Chemistry (1974), 39(24), 3506-7. CODEN: JOCEAH ISSN:0022-3263.
CAN 82:16746 AN 1975:16746 CAPLUS
Benecke, Herman P.; Wikel, James H.. Curtius rearrangement in aminimides.
Tetrahedron Letters (1972), (4), 289-92. CODEN: TELEAY ISSN:0040-4039.
CAN 76:71766 AN 1972:71766 CAPLUS
Benecke, Herman P.; Wikel, James H.. Stevens rearrangement in aminimides.
Tetrahedron Letters (1971), 37 3479-82. CODEN: TELEAY ISSN:0040-4039.
CAN 75:129165 AN 1971:529165 CAPLUS